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Article

Catechol-O-methyltransferase (COMT) polymorphism predicts rapid gait speed changes in healthy older adults.

Journal of the American Geriatrics Society - 1 Nov 2021

Sprague Briana N, Rosso Andrea L, Zhu Xiaonan, Bohnen Nicolaas I, Rosano Caterina

Abstract excerpt

IMPORTANCE: Adapting one's gait speed to external circumstances is critical for safe ambulation. Dopamine (DA), critical for adapting to increased task demands, predicts usual gait speed and may exert a greater role in complex tasks like rapid gait speed. OBJECTIVE: We hypothesized that a genotypic proxy indicator of greater prefrontal DA signaling would predict significantly faster rapid gait. DESIGN:...

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Identifiers

PMID: 34231207
DOI: 10.1111/jgs.17351
PMCID: PMC8595534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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