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Article

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice.

Acta neuropathologica communications - 20 Jun 2017

Steffen Johannes, Krohn Markus, Schwitlick Christina, Brüning Thomas, Paarmann Kristin, Pietrzik Claus U, Biverstål Henrik, Jansone Baiba, Langer Oliver, Pahnke Jens

Abstract excerpt

Amyloid-β (Aβ) deposition is one of the hallmarks of the amyloid hypothesis in Alzheimer's disease (AD). Mouse models using APP-transgene overexpression to generate amyloid plaques have shown to model only certain parts of the disease. The extent to which the data from mice can be transferred to man remains controversial. Several studies have shown convincing treatment results in reducing Aβ and enhancing...

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Source

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Identifiers

PMID: 28637503
DOI: 10.1186/s40478-017-0448-2
PMCID: PMC5480119

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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