Article
Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Abeta levels.
Neurobiology of disease - 1 Mar 2009
Simón Ana-María, Schiapparelli Lucio, Salazar-Colocho Pablo, Cuadrado-Tejedor Mar, Escribano Luis, López de Maturana Rakel, Del Río Joaquín, Pérez-Mediavilla Alberto, Frechilla Diana
Abstract excerpt
Transgenic mice expressing mutant human amyloid precursor protein (APP) develop an age-dependent amyloid pathology and memory deficits, but no overt neuronal loss. Here, in mice overexpressing wild-type human APP (hAPP(wt)) we found an early memory impairment, particularly in the water maze and to a lesser extent in the object recognition task, but beta-amyloid peptide (Abeta(42)) was barely detectable in the...
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