Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TFIIS is required for the balanced expression of the genes encoding ribosomal components under transcriptional stress.

Nucleic acids research - 1 Aug 2012

Gómez-Herreros Fernando, de Miguel-Jiménez Lola, Morillo-Huesca Macarena, Delgado-Ramos Lidia, Muñoz-Centeno María C, Chávez Sebastián

Abstract excerpt

Transcription factor IIS (TFIIS) stimulates RNA cleavage by RNA polymerase II by allowing backtracked enzymes to resume transcription elongation. Yeast cells do not require TFIIS for viability, unless they suffer severe transcriptional stress due to NTP-depleting drugs like 6-azauracil or mycophenolic acid. In order to broaden our knowledge on the role of TFIIS under transcriptional stress, we carried out a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Ribosomal
Share to Mycophenolic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ribosomal Proteins

Share to RNA Polymerase II

Share to RNA, Ribosomal

Share to Suppression, Genetic

Share to Transcriptional Elongation Factors

Share to Uracil

Source

Open in PubMed Open full text

Identifiers

PMID: 22544605
DOI: 10.1093/nar/gks340
PMCID: PMC3413141

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TFIIS is required for the balanced expression of the genes encoding ribosomal components under transcriptional stress.PMID 22544605Read ↗

The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation.Semantic proximity Read ↗

RNA polymerase II subunit Rpb9 regulates transcription elongation in vivo.Semantic proximity Read ↗

Genetic interaction between transcription elongation factor TFIIS and RNA polymerase II.Semantic proximity Read ↗

The Rpb6 subunit of fission yeast RNA polymerase II is a contact target of the transcription elongation factor TFIIS.Semantic proximity Read ↗

Genome-wide screen of fission yeast mutants for sensitivity to 6-azauracil, an inhibitor of transcriptional elongation.Semantic proximity Read ↗

The nuclear actin-related protein Act3p/Arp4p of Saccharomyces cerevisiae is involved in transcription regulation of stress genes.Semantic proximity Read ↗

Loss of Conserved rRNA Modifications in the Peptidyl Transferase Center Leads to Diminished Protein Synthesis and Cell Growth in Budding Yeast.Semantic proximity Read ↗

Analysis of gene induction and arrest site transcription in yeast with mutations in the transcription elongation machinery.Semantic proximity Read ↗

Mutations in RNA polymerase II and elongation factor SII severely reduce mRNA levels in Saccharomyces cerevisiae.Semantic proximity Read ↗

Yeast Swd2 is essential because of antagonism between Set1 histone methyltransferase complex and APT (associated with Pta1) termination factor.Semantic proximity Read ↗

Inhibiting ribosome assembly and ribosome translation have distinctly different effects on the abundance and paralogue composition of ribosomal protein mRNAs in <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

Futile cycle of transcription initiation and termination modulates the response to nucleotide shortage in S. cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.