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Article

Altered rRNA processing disrupts nuclear RNA homeostasis via competition for the poly(A)-binding protein Nab2.

Nucleic acids research - 18 Nov 2020

Aguilar Lisbeth-Carolina, Paul Biplab, Reiter Taylor, Gendron Louis, Arul Nambi Rajan Arvind, Montpetit Rachel, Trahan Christian, Pechmann Sebastian, Oeffinger Marlene, Montpetit Ben

Abstract excerpt

RNA-binding proteins (RBPs) are key mediators of RNA metabolism. Whereas some RBPs exhibit narrow transcript specificity, others function broadly across both coding and non-coding RNAs. Here, in Saccharomyces cerevisiae, we demonstrate that changes in RBP availability caused by disruptions to distinct cellular processes promote a common global breakdown in RNA metabolism and nuclear RNA homeostasis. Our data...

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Share to Exosome Multienzyme Ribonuclease Complex
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33137177
DOI: 10.1093/nar/gkaa964
PMCID: PMC7672433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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