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Article

Individual letters of the RNA polymerase II CTD code govern distinct gene expression programs in fission yeast.

Proceedings of the National Academy of Sciences of the United States of America - 18 Mar 2014

Schwer Beate, Bitton Danny Asher, Sanchez Ana M, Bähler Jürg, Shuman Stewart

Abstract excerpt

The primary structure and phosphorylation pattern of the tandem Y(1)S(2)P(3)T(4)S(5)P(6)S(7) repeats of the RNA polymerase II carboxyl-terminal domain (CTD) comprise an informational code that coordinates transcription, chromatin modification, and RNA processing. To gauge the contributions of individual CTD coding "letters" to gene expression, we analyzed the poly(A)(+) transcriptomes of fission yeast mutants...

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Identifiers

PMID: 24591591
DOI: 10.1073/pnas.1321842111
PMCID: PMC3964054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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