Article
KRAS mutation detection in colorectal cancer by a commercially available gene chip array compares well with Sanger sequencing.
Clinica chimica acta; international journal of clinical chemistry - 17 Aug 2011
French Deborah, Smith Andrew, Powers Martin P, Wu Alan H B
Abstract excerpt
BACKGROUND: Binding of a ligand to the epidermal growth factor receptor (EGFR) stimulates various intracellular signaling pathways resulting in cell cycle progression, proliferation, angiogenesis and apoptosis inhibition. KRAS is involved in signaling pathways including RAF/MAPK and PI3K and mutations in this gene result in constitutive activation of these pathways, independent of EGFR activation. Seven mutations...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.