Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Eprobe-mediated screening system for somatic mutations in the KRAS locus.

Oncology reports - 1 Jun 2015

Atsumi Jun, Hanami Takeshi, Enokida Yasuaki, Ogawa Hiroomi, Delobel Diane, Mitani Yasumasa, Kimura Yasumasa, Soma Takahiro, Tagami Michihira, Takase Yoshiaki, Ichihara Tatsuo, Takeyoshi Izumi, Usui Kengo, Hayashizaki Yoshihide, Shimizu Kimihiro

Abstract excerpt

Activating mutations in the Kirsten rat sarcoma viral oncogene homolog (KRAS) loci are largely predictive of resistance to epidermal growth factor receptor (EGFR) therapy in colorectal cancer (CRC). A highly sensitive detection system for the KRAS gene mutations is urgently needed; however, conventional methods have issues with feasibility and cost performance. Here, we describe a novel detection system using a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Mutation

Share to Nucleic Acid Denaturation

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins p21(ras)

Share to ras Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25823645
DOI: 10.3892/or.2015.3883
PMCID: PMC4431451

Genes

KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Eprobe-mediated screening system for somatic mutations in the KRAS locus.PMID 25823645Read ↗

SensiScreen®KRAS exon 2-sensitive simplex and multiplex real-time PCR-based assays for detection of KRAS exon 2 mutations.Semantic proximity Read ↗

Multi-Center Evaluation of the Fully Automated PCR-Based Idylla™ KRAS Mutation Assay for Rapid KRAS Mutation Status Determination on Formalin-Fixed Paraffin-Embedded Tissue of Human Colorectal CancerSemantic proximity Read ↗

Detection of KRAS codon 12 and 13 mutations by mutant-enriched PCR assay.Semantic proximity Read ↗

A PNA-mediated clamping PCR for routine detection of KRAS mutations in colorectal carcinoma.Semantic proximity Read ↗

KRAS mutations detection methodology: from RFLP to CRISPR/Cas based methods.Semantic proximity Read ↗

Sensitive detection of trace amounts of KRAS codon 12 mutations by a fast and novel one-step technique.Semantic proximity Read ↗

KRAS gene mutation in a series of unselected colorectal carcinoma patients with prognostic morphological correlations: a pyrosequencing method improved by nested PCR.Semantic proximity Read ↗

Validation of a Multiplex Allele-Specific Polymerase Chain Reaction Assay for Detection of KRAS Gene Mutations in Formalin-Fixed, Paraffin-Embedded Tissues from Colorectal Cancer Patients.Semantic proximity Read ↗

COLD-PCR enhanced melting curve analysis improves diagnostic accuracy for KRAS mutations in colorectal carcinomaSemantic proximity Read ↗

Multiplex detection of KRAS mutations by a matrix-assisted laser desorption/ionization-time of flight mass spectrometry assay.Semantic proximity Read ↗

A novel mutant-enriched liquidchip technology for the qualitative detection of somatic mutations in KRAS gene from both serum and tissue samples.Semantic proximity Read ↗

Sensitive detection of KRAS mutations in archived formalin-fixed paraffin-embedded tissue using mutant-enriched PCR and reverse-hybridization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.