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Article

Role of CLU, PICALM, and TNK1 Genotypes in Aging With and Without Alzheimer's Disease.

Molecular neurobiology - 1 May 2018

Seripa Davide, Panza Francesco, Paroni Giulia, D'Onofrio Grazia, Bisceglia Paola, Gravina Carolina, Urbano Maria, Lozupone Madia, Solfrizzi Vincenzo, Bizzarro Alessandra, Boccardi Virginia, Piccininni Chiara, Daniele Antonio, Logroscino Giancarlo, Mecocci Patrizia, Masullo Carlo, Greco Antonio

Abstract excerpt

Healthy and impaired cognitive aging may be associated to different prevalences of single-nucleotide polymorphisms (SNPs). In a multicenter case-control association study, we studied the SNPs rs11136000 (clusterin, CLU), rs541458 (phosphatidylinositol binding clatrin assembly protein, PICALM), and rs1554948 (transcription factor A, and tyrosine kinase, non-receptor, 1, TNK1) according to the three age groups...

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Source

Identifiers

PMID: 28631188
DOI: 10.1007/s12035-017-0547-x

Genes

TNK1
PICALM
CLU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Role of CLU, PICALM, and TNK1 Genotypes in Aging With and Without Alzheimer's Disease.PMID 28631188Read ↗

LACK OF ASSOCIATIONS BETWEEN CLU AND PICALM GENE POLYMORPHISMS AND ALZHEIMER'S DISEASE IN A TURKISH POPULATION.Semantic proximity Read ↗

Implication of common and disease specific variants in CLU, CR1, and PICALM.Semantic proximity Read ↗

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.Semantic proximity Read ↗

Effect of CLU and PICALM polymorphisms on AD risk: A study from south India.Semantic proximity Read ↗

Association between CLU gene rs11136000 polymorphism and Alzheimer's disease: an updated meta-analysis.Semantic proximity Read ↗

Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old.Semantic proximity Read ↗

Genetic association between clusterin polymorphisms and Alzheimer's disease in a Japanese population.Semantic proximity Read ↗

Lack of association of CR1, PICALM and CLU gene polymorphisms with Alzheimer disease in a Polish population.Semantic proximity Read ↗

Replication of CLU, CR1, and PICALM associations with alzheimer disease.Semantic proximity Read ↗

Single Nucleotide Polymorphism rs11136000 of CLU Gene (Clusterin, ApoJ) and the Risk of Late-Onset Alzheimer's Disease in a Central European Population.Semantic proximity Read ↗

Associations between CLU polymorphisms and memory performance: The role of serum lipids in Alzheimer's disease.Semantic proximity Read ↗

Association of CLU and PICALM variants with Alzheimer's disease.Semantic proximity Read ↗

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