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Article

Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old.

Neurobiology of aging - 1 Mar 2011

Mengel-From Jonas, Christensen Kaare, McGue Matt, Christiansen Lene

Abstract excerpt

Recently, two large, and independent genome wide association studies of late-onset Alzheimer's disease (AD) established association with the same rs11136000 variation in the clusterin (CLU) gene. In addition, one variation, rs3851179, in the phosphatidylinositol binding clathrin assembly protein (PICALM) gene and one variation, rs6656401, in the complement component (3b/4b) receptor 1 (CR) gene were associated...

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Source

Open in PubMed Open full text

Identifiers

PMID: 20739100
DOI: 10.1016/j.neurobiolaging.2010.07.016
PMCID: PMC3042035

Genes

CLU
PICALM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old.PMID 20739100Read ↗

Implication of common and disease specific variants in CLU, CR1, and PICALM.Semantic proximity Read ↗

Lack of association of CR1, PICALM and CLU gene polymorphisms with Alzheimer disease in a Polish population.Semantic proximity Read ↗

The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels.Semantic proximity Read ↗

Effect of CLU and PICALM polymorphisms on AD risk: A study from south India.Semantic proximity Read ↗

The three new pathways leading to Alzheimer's disease.Semantic proximity Read ↗

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.Semantic proximity Read ↗

Associations between CLU polymorphisms and memory performance: The role of serum lipids in Alzheimer's disease.Semantic proximity Read ↗

LACK OF ASSOCIATIONS BETWEEN CLU AND PICALM GENE POLYMORPHISMS AND ALZHEIMER'S DISEASE IN A TURKISH POPULATION.Semantic proximity Read ↗

Association of CLU and PICALM variants with Alzheimer's disease.Semantic proximity Read ↗

Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.Semantic proximity Read ↗

A Network of Genetic Effects on Non-Demented Cognitive Aging: Alzheimer's Genetic Risk (CLU + CR1 + PICALM) Intensifies Cognitive Aging Genetic Risk (COMT + BDNF) Selectively for APOEɛ4 Carriers.Semantic proximity Read ↗

Exome-wide analysis reveals role of <i>LRP1</i> and additional novel loci in cognitionSemantic proximity Read ↗

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