Article
Lack of association of CR1, PICALM and CLU gene polymorphisms with Alzheimer disease in a Polish population.
Neurologia i neurochirurgia polska - 1 Jan 2000
Klimkowicz-Mrowiec Aleksandra, Sado Małgorzata, Dziubek Anna, Dziedzic Tomasz, Pera Joanna, Szczudlik Andrzej, Slowik Agnieszka
Abstract excerpt
BACKGROUND AND PURPOSE: Recent genome-wide association studies have indicated 3 new susceptibility loci for Alzheimer disease (AD): complement receptor 1 (CR1), clusterin (CLU), and the phosphatidylinositol-binding clathrin assembly protein (PICALM). We investigated the influence of the rs6656401 single nucleotide polymorphisms (SNP) of the CR1 gene, the rs3851179 SNP of the PICALM gene, and the rs11136000 SNP of...
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