Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proinflammatory Actions of Glucocorticoids: Glucocorticoids and TNFα Coregulate Gene Expression In Vitro and In Vivo

6 Jun 2012

Abstract excerpt

Synthetic glucocorticoids are widely used for treatment of many inflammatory diseases. However, long-term glucocorticoid treatment can cause a variety of negative side effects. A genome-wide microarray analysis was performed in human lung A549 cells to identify genes regulated by both the antiinflammatory steroid dexamethasone (Dex) and the proinflammatory cytokine TNFα. Unexpectedly, we discovered that numerous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Hormones and Disorders
Share to Cytokine Signaling Pathways and Interactions
Share to Estrogen and related hormone effects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22673229
DOI: 10.1210/en.2012-1020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proinflammatory Actions of Glucocorticoids: Glucocorticoids and TNFα Coregulate Gene Expression In Vitro and In VivoPMID 22673229Read ↗

Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid ReceptorSemantic proximity Read ↗

SMARCA2 is an essential and potent cofactor for a specific subset of the glucocorticoid response in A549 cellsSemantic proximity Read ↗

RNA-Seq Analysis of Activated PBMC Treated With LMWF5A Predicts an Anti-Inflammatory Mode of Action and Similar Drug Targets to DexamethasoneSemantic proximity Read ↗

Cistrome-based Cooperation between Airway Epithelial Glucocorticoid Receptor and NF-κB Orchestrates Anti-inflammatory EffectsSemantic proximity Read ↗

Global Gene Expression Analysis in Human Uterine Epithelial Cells Defines New Targets of Glucocorticoid and Estradiol Antagonism1Semantic proximity Read ↗

Development of novel treatment strategies for inflammatory diseases—similarities and divergence between glucocorticoids and GILZSemantic proximity Read ↗

The Interactome of the Glucocorticoid Receptor and Its Influence on the Actions of Glucocorticoids in Combatting Inflammatory and Infectious DiseasesSemantic proximity Read ↗

Context-dependent Cooperation between Nuclear Factor κB (NF-κB) and the Glucocorticoid Receptor at a TNFAIP3 Intronic EnhancerSemantic proximity Read ↗

Anti-inflammatory Actions of Glucocorticoids: Molecular MechanismsSemantic proximity Read ↗

Immune regulation by glucocorticoids can be linked to cell type–dependent transcriptional responsesSemantic proximity Read ↗

The Glucocorticoid Receptor: Isoforms, Functions, and Contribution to Glucocorticoid SensitivitySemantic proximity Read ↗

RNA sequencing analysis of human podocytes reveals glucocorticoid regulated gene networks targeting non-immune pathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.