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Article

Alternative Polyadenylation Contributes to Fibroblast Senescence in Pulmonary Fibrosis

30 Jul 2025

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a prevalent and deadly age-related disease characterized by chronic, progressive, and irreversible fibrosis. A key effector cell population in the fibroproliferative response is the fibroblasts. Fibroblast cell senescence gradually worsens during aging, and the acquisition of a senescence-associated secretory phenotype (SASP) turns senescent fibroblasts into pro-inflammatory...

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PMID: 40738116
DOI: 10.1111/acel.70179

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