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Article

Modulatory effects of Ampicillin/Sulbactam on glial glutamate transporters and metabotropic glutamate receptor 1 as well as reinstatement to cocaine-seeking behavior.

Behavioural brain research - 14 Aug 2017

Hammad Alaa M, Alasmari Fawaz, Althobaiti Yusuf S, Sari Youssef

Abstract excerpt

Glutamatergic system has an important role in cocaine-seeking behavior. Studies have reported that chronic exposure to cocaine induces downregulation of glutamate transporter-1 (GLT-1) and cystine/glutamate exchanger (xCT) in the central reward brain regions. Ceftriaxone, a β-lactam antibiotic, restored GLT-1 expression and consequently reduced cue-induced reinstatement of cocaine-seeking behavior. In this study,...

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Identifiers

PMID: 28624317
DOI: 10.1016/j.bbr.2017.06.017
PMCID: PMC5551456

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