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Article

In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis.

PLoS computational biology - 1 Jun 2017

Colman Michael A, Ni Haibo, Liang Bo, Schmitt Nicole, Zhang Henggui

Abstract excerpt

A recent experimental study investigating patients with lone atrial fibrillation identified six novel mutations in the KCNA5 gene. The mutants exhibited both gain- and loss-of-function of the atrial specific ultra-rapid delayed rectifier K+ current, IKur. The aim of this study is to elucidate and quantify the functional impact of these KCNA5 mutations on atrial electrical activity. A multi-scale model of the...

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Atrial Fibrillation
Computer Simulation
Heart Conduction System
Ion Channel Gating
Models, Cardiovascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Genetic

Signal Transduction

Structure-Activity Relationship

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Open in PubMed Open full text

Identifiers

PMID: 28622331
DOI: 10.1371/journal.pcbi.1005587
PMCID: PMC5493429

Genes

KCNA5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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