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Article

Pro-arrhythmogenic effects of the S140G KCNQ1 mutation in human atrial fibrillation - insights from modelling.

The Journal of physiology - 15 Sept 2012

Kharche Sanjay, Adeniran Ismail, Stott Jonathan, Law Phillip, Boyett Mark R, Hancox Jules C, Zhang Henggui

Abstract excerpt

Functional analysis has shown that the missense gain-in-function KCNQ1 S140G mutation associated with familial atrial fibrillation produces an increase of the slow delayed rectifier potassium current (I(Ks)). Through computer modelling, this study investigated mechanisms by which the KCNQ1 S140G mutation promotes and perpetuates atrial fibrillation. In simulations, Courtemanche et al.'s model of human atrial cell...

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Action Potentials
Atrial Fibrillation
Computer Simulation
KCNQ1 gene
Heart Atria

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

KCNQ1 Potassium Channel

Models, Cardiovascular

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Open in PubMed Open full text

Identifiers

PMID: 22508963
DOI: 10.1113/jphysiol.2012.229146
PMCID: PMC3477754

Genes

KCNQ1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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