Genetic mutations and arrhythmia: simulation from DNA to electrocardiogram.

Abstract excerpt

In the past two decades, mutations in cardiac ion channels have been shown to underlie a number of rare inherited cardiac arrhythmias. Defects in cardiac Na(+) channels can disrupt channel gating and cause electrical abnormalities that increase susceptibility to cardiac arrhythmia. Dozens of mutations have been identified in the gene SCN5A, which encodes the alpha subunit of the cardiac Na(+) channel, and have...

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