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Article

In-silico investigations of the functional impact of KCNA5 mutations on atrial mechanical dynamics.

Journal of molecular and cellular cardiology - 1 Oct 2017

Ni Haibo, Adeniran Ismail, Zhang Henggui

Abstract excerpt

A recent study has identified six novel genetic variations (D322H, E48G, A305T, D469E, Y155C, P488S) in KCNA5 (encoding Kv1.5 which carries the atrial-specific ultra-rapid delayed rectifier current, IKur) in patients with early onset of lone atrial fibrillation. These mutations are distinctive, resulting in either gain-of-function (D322H, E48G, A305T) or loss-of-function (D469E, Y155C, P488S) of IKur channels....

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Source

Identifiers

PMID: 28803858
DOI: 10.1016/j.yjmcc.2017.08.005

Genes

KCNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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