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Article

Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation

13 Jun 2006

Abstract excerpt

Atrial fibrillation is a rhythm disorder characterized by chaotic electrical activity of cardiac atria. Predisposing to stroke and heart failure, this common condition is increasingly recognized as a heritable disorder. To identify genetic defects conferring disease susceptibility, patients with idiopathic atrial fibrillation, lacking traditional risk factors, were evaluated. Genomic DNA scanning revealed a...

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PMID: 16772329
DOI: 10.1093/hmg/ddl143

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