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Article

Dysfunctional Nav1.5 channels due to SCN5A mutations.

Experimental biology and medicine (Maywood, N.J.) - 1 Jun 2018

Han Dan, Tan Hui, Sun Chaofeng, Li Guoliang

Abstract excerpt

The voltage-gated sodium channel 1.5 (Nav1.5), encoded by the SCN5A gene, is responsible for the rising phase of the action potential of cardiomyocytes. The sodium current mediated by Nav1.5 consists of peak and late components (INa-P and INa-L). Mutant Nav1.5 causes alterations in the peak and late sodium current and is associated with an increasingly wide range of congenital arrhythmias. More than 400 mutations...

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Identifiers

PMID: 29806494
DOI: 10.1177/1535370218777972
PMCID: PMC6022915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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