Article
Mutation in Caenorhabditis elegans Krüppel-like factor, KLF-3 results in fat accumulation and alters fatty acid composition.
Experimental cell research - 10 Sept 2009
Zhang Jun, Yang Chuan, Brey Christopher, Rodriguez Marilis, Oksov Yelena, Gaugler Randy, Dickstein Ellen, Huang Cheng-Han, Hashmi Sarwar
Abstract excerpt
In vertebrates, adipose tissue stores energy in the form of fat. Fat storage is tightly controlled by and dynamically balanced with energy expenditure under physiological settings; the perturbation of fat in either excess (obese) or deficit (lipodystrophy) has devastating pathologic consequences in the fueling of homeostasis and organismal fitness. The process by which fat storage is coordinated through positive...
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