Article
Hepatocellular benign tumors-from molecular classification to personalized clinical care.
Gastroenterology - 1 May 2013
Nault Jean-Charles, Bioulac-Sage Paulette, Zucman-Rossi Jessica
Abstract excerpt
Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) are benign hepatocellular tumors that develop most frequently in women without cirrhosis. Genomic approaches have identified signaling pathways related to these benign hepatocyte proliferations. FNH, a polyclonal lesion, is characterized by local vascular abnormalities and heterogeneous activation of Wnt/β-catenin and transforming growth factor β...
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