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Article

Predictive Patterns of Glutamine Synthetase Immunohistochemical Staining in CTNNB1-mutated Hepatocellular Adenomas.

The American journal of surgical pathology - 1 Apr 2021

Sempoux Christine, Gouw Annette S H, Dunet Vincent, Paradis Valérie, Balabaud Charles, Bioulac-Sage Paulette

Abstract excerpt

Some hepatocellular adenoma (HCA) subtypes are characterized by different CTNNB1 mutations, leading to different beta-catenin activation levels, hence variable immunostaining patterns of glutamine synthetase (GS) expression, and different risks of malignant transformation. In a retrospective multicentric study of 63 resected inflammatory (n=33) and noninflammatory (n=30) molecularly confirmed CTNNB1-mutated...

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PMID: 33560657
DOI: 10.1097/PAS.0000000000001675

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