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Genetic determinants of HbF in Saudi Arabian and African Benin haplotype sickle cell anemia

14 Jun 2017

Abstract excerpt

Each of the major haplotypes of the HBB gene cluster in sickle cell anemia are associated with different fetal hemoglobin (HbF) levels. Four of these HBB haplotypes originated in Africa (Benin, Central African Republic, Cameroon, and Senegal) while the Arab-Indian haplotype arose independently in the Arabian Peninsula or in India. Although HbF is the major modulator of disease severity, the genetic elements that...

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PMID: 28612458
DOI: 10.1002/ajh.24822

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