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Article

Local RNA flexibility perturbation of the IRES element induced by a novel ligand inhibits viral RNA translation

16 Mar 2015

Abstract excerpt

The internal ribosome entry site (IRES) element located at the 5'untranslated genomic region of various RNA viruses mediates cap-independent initiation of translation. Picornavirus IRES activity is highly dependent on both its structural organization and its interaction with host factors. Small molecules able to interfere with RNA function are valuable candidates for antiviral agents. Here we show that a small...

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Identifiers

PMID: 25775053
DOI: 10.1080/15476286.2015.1025190

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