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Article

Conformational inhibition of the hepatitis C virus internal ribosome entry site RNA.

Nature chemical biology - 1 Nov 2009

Parsons Jerod, Castaldi M Paola, Dutta Sanjay, Dibrov Sergey M, Wyles David L, Hermann Thomas

Abstract excerpt

The internal ribosome entry site (IRES), a highly conserved structured element of the hepatitis C virus (HCV) genomic RNA, is an attractive target for antiviral drugs. Here we show that benzimidazole inhibitors of the HCV replicon act by conformational induction of a widened interhelical angle in the IRES subdomain IIa, which facilitates the undocking of subdomain IIb from the ribosome and ultimately leads to...

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Identifiers

PMID: 19767736
DOI: 10.1038/nchembio.217
PMCID: PMC2770845

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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