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Article

A Herpesviral Immediate Early Protein Promotes Transcription Elongation of Viral Transcripts.

mBio - 13 Jun 2017

Fox Hannah L, Dembowski Jill A, DeLuca Neal A

Abstract excerpt

Herpes simplex virus 1 (HSV-1) genes are transcribed by cellular RNA polymerase II (RNA Pol II). While four viral immediate early proteins (ICP4, ICP0, ICP27, and ICP22) function in some capacity in viral transcription, the mechanism by which ICP22 functions remains unclear. We observed that the FACT complex (comprised of SSRP1 and Spt16) was relocalized in infected cells as a function of ICP22. ICP22 was also...

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Source

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Identifiers

PMID: 28611249
DOI: 10.1128/mBio.00745-17
PMCID: PMC5472187

Genes

SSRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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