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HSV-1 ICP22 condensates impair host transcription by depleting promoter RNAPII Ser-2P occupation

18 Feb 2025

Abstract excerpt

Herpes simplex virus type I (HSV-1) infection-induced host transcript ion shutdown is one of the most critical hallmarks of viral lytic infection. However, how HSV-1 and which viral factors accomplish this dramatic effect is not well understood. In this study, we show that ICP22-defined condensates shutdown host global transcription but facilitate viral transcription. This is independent of its effects on viral...

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PMID: 40041865
DOI: 10.3389/fmicb.2025.1538737

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