Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy.

doi:10.1158/1078-0432.CCR-15-2823

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Article

Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2016

Hertz Daniel L, Owzar Kouros, Lessans Sherrie, Wing Claudia, Jiang Chen, Kelly William Kevin, Patel Jai, Halabi Susan, Furukawa Yoichi, Wheeler Heather E, Sibley Alexander B, Lassiter Cameron, Weisman Lois, Watson Dorothy, Krens Stefanie D, Mulkey Flora, Renn Cynthia L, Small Eric J, Febbo Phillip G, Shterev Ivo, Kroetz Deanna L, Friedman Paula N, Mahoney John F, Carducci Michael A, Kelley Michael J, Nakamura Yusuke, Kubo Michiaki, Dorsey Susan G, Dolan M Eileen, Morris Michael J, Ratain Mark J, McLeod Howard L

Abstract excerpt

PURPOSE: Discovery of SNPs that predict a patient's risk of docetaxel-induced neuropathy would enable treatment individualization to maximize efficacy and avoid unnecessary toxicity. The objectives of this analysis were to discover SNPs associated with docetaxel-induced neuropathy and mechanistically validate these associations in preclinical models of drug-induced neuropathy. EXPERIMENTAL DESIGN: A genome-wide...

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PMID: 27143689
DOI: 10.1158/1078-0432.CCR-15-2823
PMCID: PMC5050068

Genes

VAC14

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