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Article

Downregulation of histone methyltransferase EHMT2 in CD4+ T-cells may protect HTLV-1-infected individuals against HAM/TSP development.

Archives of virology - 1 Oct 2017

Colaço Camila Schoueri, de Matos Adriano Reis, Estrêla Martha Silva, Rocha-Júnior Maurício Cristiano, Otaguiri Kátia Kaori, Rodrigues Evandra Strazza, Takayanagui Osvaldo Massaiti, Covas Dimas Tadeu, Kashima Simone, Pittella Silva Fabio, Haddad Rodrigo

Abstract excerpt

Approximately 5% of human T-cell leukemia virus type 1 (HTLV-1)-infected individuals will develop one of the HTLV-1-related diseases, such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) or adult T-cell leukemia. However, the mechanisms responsible for the appearance of symptoms have not been fully clarified. It is believed that viral factors, host genetic and epigenetic mechanisms are...

Read the complete abstract on PubMed

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Share to CD4-Positive T-Lymphocytes
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Histocompatibility Antigens

Share to Histone-Lysine N-Methyltransferase

Share to Human T-lymphotropic virus 1

Share to Paraparesis, Tropical Spastic

Source

Identifiers

PMID: 28608127
DOI: 10.1007/s00705-017-3428-8

Genes

EHMT2
EHMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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