Article

Dysregulation of the tumor suppressor Menin and its target Bach2 in HTLV-1 infection

2024-10-02

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> The tumor suppressor Menin, prone to mutations in both hereditary and sporadic endocrine tumors, along with its direct target Bach2, plays a crucial role in preventing autoimmunity by regulating CD4+ T cell senescence and maintaining cytokine homeostasis. Since human T-cell leukemia virus type 1 (HTLV-1) primarily infects CD4+ T cells, and its dysregulation contr...

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Literature Corpus work: d1e1e7c9-9bf1-5450-b535-db9a311b6c3c
DOI: 10.21203/rs.3.rs-4889456/v1

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