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Chemoresistance of colorectal cancer to 5-fluorouracil is associated with silencing of the BNIP3 gene through aberrant methylation

1 Jan 2017

Abstract excerpt

Purpose To investigate the correlation between chemoresistance of colorectal cancer to 5-fluorouracil and BNIP3 and the underlying mechanism. Methods BNIP3 protein in specimens was evaluated using immunohistochemistry. Semi-quantitative reverse transcription PCR and Western blot was employed to assay gene expression. The promoter methylation status of BNIP3 was examined by methylation-specific PCR. Drug...

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Share to Colorectal Cancer Treatments and Studies
Share to Epigenetics and DNA Methylation
Share to Genetic factors in colorectal cancer

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PMID: 28607593
DOI: 10.7150/jca.18171

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