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Article

BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF.

Oncogene - 24 Jul 2003

Kothari Shilpa, Cizeau Jeannick, McMillan-Ward Eileen, Israels Sara J, Bailes Michelle, Ens Karen, Kirshenbaum Lorrie A, Gibson Spencer B

Abstract excerpt

Hypoxic regions within solid tumors are often resistant to chemotherapy and radiation. BNIP3 (Bcl-2/E1B 19 kDa interacting protein) is a proapoptotic member of the Bcl-2 family that is expressed in hypoxic regions of tumors. During hypoxia, BNIP3 expression is increased in many cell types and upo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12879018
DOI: 10.1038/sj.onc.1206666

Genes

BNIP3
EGF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12879018-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF.PMID 12879018Read ↗

Regulation of BNIP3 in Normal and Cancer CellsSemantic proximity Read ↗

Truncated forms of BNIP3 act as dominant negatives inhibiting hypoxia-induced cell death.Semantic proximity Read ↗

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Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3Semantic proximity Read ↗

Hypoxia induces the expression of the pro-apoptotic gene BNIP3Semantic proximity Read ↗

BNIP3 Expression Is Linked with Hypoxia-Regulated Protein Expression and with Poor Prognosis in Non–Small Cell Lung CancerSemantic proximity Read ↗

<i>BNIP3</i> Is an RB/E2F Target Gene Required for Hypoxia-Induced AutophagySemantic proximity Read ↗

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Antagonism of E2F-1 regulated Bnip3 transcription by NF-κB is essential for basal cell survivalSemantic proximity Read ↗

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