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Article

Downregulation of fibulin-3 gene by promoter methylation in colorectal cancer predicts adverse prognosis

1 Jan 2011

Abstract excerpt

Fibulin-3 gene has been identified as an antagonist of angiogenesis. We investigated the protein expression and promoter methylation status of fibulin-3 gene in colorectal cancer (CRC) and analyzed its correlation with clinicopathological factors. The study population enrolled 85 paired CRC specimens and adjacent normal tissues, as well as 32 cases of colorectal adenoma. Genomic DNA was extracted from...

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PMID: 21744999
DOI: 10.4149/neo_2011_05_441

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