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Aberrant Methylation and Silencing of the<i>BNIP3</i>Gene in Colorectal and Gastric Cancer

1 Feb 2005

Abstract excerpt

BNIP3 protein is a proapoptotic member of the Bcl-2 family that is expressed in hypoxic regions of tumors. To examine its role in the progression of gastrointestinal cancer, we examined the expression and DNA methylation status of BNIP3 gene in a panel of colorectal and gastric cancer cell lines. BNIP3 was not expressed in 14 of the 24 cell lines tested, and its absence was not caused by gene mutation or by...

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PMID: 15709167
DOI: 10.1158/1078-0432.1021.11.3

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Aberrant Methylation and Silencing of the<i>BNIP3</i>Gene in Colorectal and Gastric CancerPMID 15709167Read ↗

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