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PBX3 promotes migration and invasion of colorectal cancer cells via activation of MAPK/ERK signaling pathway

1 Jan 2014

Abstract excerpt

AIM: To investigate the role of pre-B-cell leukemia homeobox (PBX)3 in migration and invasion of colorectal cancer (CRC) cells. METHODS: We detected PBX3 expression in five cell lines and surgical specimens from 111 patients with CRC using real-time reverse transcription-polymerase chain reaction. We forced expression of PBX3 in low metastatic HT-29 and SW480 cells and knocked down expression of PBX3 in highly...

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PMID: 25561793
DOI: 10.3748/wjg.v20.i48.18260

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