Article
Identification of genes associated with testicular germ cell tumor susceptibility through a transcriptome-wide association study.
American journal of human genetics - 6 Mar 2025
Ugalde-Morales Emilio, Wilf Rona, Pluta John, Ploner Alexander, Fan Mengyao, Damra Mohammad, Aben Katja K, Anson-Cartwright Lynn, Chen Chu, Cortessis Victoria K, Daneshmand Siamak, Ferlin Alberto, Gamulin Marija, Gietema Jourik A, Gonzalez-Niera Anna, Grotmol Tom, Hamilton Robert J, Harland Mark, Haugen Trine B, Hauser Russ, Hildebrandt Michelle A T, Karlsson Robert, Kiemeney Lambertus A, Kim Jung, Lessel Davor, Lothe Ragnhild A, Loveday Chey, Chanock Stephen J, McGlynn Katherine A, Meijer Coby, Nead Kevin T, Nsengimana Jeremie, Popovic Maja, Rafnar Thorunn, Richiardi Lorenzo, Rocca Maria S, Schwartz Stephen M, Skotheim Rolf I, Stefansson Kari, Stewart Douglas R, Turnbull Clare, Vaughn David J, Winge Sofia B, Zheng Tongzhang, Monteiro Alvaro N, Almstrup Kristian, Kanetsky Peter A, Nathanson Katherine L, Wiklund Fredrik
Abstract excerpt
Transcriptome-wide association studies (TWASs) have the potential to identify susceptibility genes associated with testicular germ cell tumors (TGCTs). We conducted a comprehensive TGCT TWAS by integrating genome-wide association study (GWAS) summary data with predicted expression models from normal testis, TGCT tissues, and a cross-tissue panel that encompasses shared regulatory features across 22 normal...
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