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Article

Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.

Nature genetics - 1 Jun 2013

Ruark Elise, Seal Sheila, McDonald Heather, Zhang Feng, Elliot Anna, Lau Kingwai, Perdeaux Elizabeth, Rapley Elizabeth, Eeles Rosalind, Peto Julian, Kote-Jarai Zsofia, Muir Kenneth, Nsengimana Jeremie, Shipley Janet, Bishop D Timothy, Stratton Michael R, Easton Douglas F, Huddart Robert A, Rahman Nazneen, Turnbull Clare

Abstract excerpt

Testicular germ cell tumor (TGCT) is the most common cancer in young men and is notable for its high familial risks. So far, six loci associated with TGCT have been reported. From genome-wide association study (GWAS) analysis of 307,291 SNPs in 986 TGCT cases and 4,946 controls, we selected for follow-up 694 SNPs, which we genotyped in a further 1,064 TGCT cases and 10,082 controls from the UK. We identified SNPs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasms, Germ Cell and Embryonal

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Source

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Identifiers

PMID: 23666240
DOI: 10.1038/ng.2635
PMCID: PMC3680037

Genes

DAZL
PRDM14
PITX1
TERT

Provenance

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