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Article

Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation.

Haematologica - 1 Oct 2014

Vinjamur Divya S, Wade Kristen J, Mohamad Safa F, Haar Jack L, Sawyer Stephen T, Lloyd Joyce A

Abstract excerpt

The Krüppel-like transcription factors KLF1 and KLF2 are essential for embryonic erythropoiesis. They can partially compensate for each other during mouse development, and coordinately regulate numerous erythroid genes, including the β-like globins. Simultaneous ablation of KLF1 and KLF2 results in earlier embryonic lethality and severe anemia. In this study, we determine that this anemia is caused by a paucity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25150253
DOI: 10.3324/haematol.2014.104943
PMCID: PMC4181252

Genes

KLF2
KLF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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