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Article

Severe anemia caused by dominant mutations in Krüppel-like factor 1 (KLF1).

Mutation research. Reviews in mutation research - 1 Jan 2000

Kulczynska-Figurny Klaudia, Bieker James J, Siatecka Miroslawa

Abstract excerpt

The etiology and severity of anemia, a common blood disorder, are diverse. Dominant mutations in Krüppel-like factor 1 (KLF1/EKLF) underlie the molecular basis for some of them. KLF1 is a zinc finger transcription factor that plays an essential role in red blood cell proliferation and differentiation. Mutations have been identified in the KLF1 gene that cause hematologic diseases. Two of these alter one allele...

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Identifiers

PMID: 33339573
DOI: 10.1016/j.mrrev.2020.108336
PMCID: PMC10199782

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