Interleukin-1 beta (C-511T) genetic polymorphism is associated with cognitive performance in elderly males without dementia.

doi:10.1016/j.neurobiolaging.2008.10.002

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Article

Interleukin-1 beta (C-511T) genetic polymorphism is associated with cognitive performance in elderly males without dementia.

Neurobiology of aging - 1 Nov 2010

Tsai Shih-Jen, Hong Chen-Jee, Liu Mu-En, Hou Sheue-Jane, Yen Feng-Chang, Hsieh Cheng-Hsi, Liou Ying-Jay

Abstract excerpt

Interleukin-1 beta (IL-1 beta), a proinflammatory cytokine, plays a significant role in age-related changes in long-term potentiation (a biological substrate for learning and/or memory) in the hippocampus of experimental animals. This study tests the hypothesis that a biallelic functional polymorphism in the promoter region (position-511) (rs16944) of the IL-1 beta gene is associated with cognitive performance in...

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PMID: 19013689
DOI: 10.1016/j.neurobiolaging.2008.10.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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