Article
Immunoinflammatory Markers in Patients with Affective Disorders: Genetic Polymorphisms, Peripheral Cytokine Levels, and Expression of IL-1β, IL-13, TNF-β, and TGF-α in Peripheral Blood Mononuclear Cells.
Biochemistry. Biokhimiia - 1 May 2026
Mikhalitskaya Ekaterina V, Levchuk Lyudmila A, Boiko Anastasia S, Vyalova Natalya M, Epimakhova Elena V, Paderina Diana Z, Roschina Olga V, Simutkin German G, Bokhan Nikolay A, Ivanova Svetlana A
Abstract excerpt
Cytokines play a critical role in brain functioning by modulating neurotransmitter and energy metabolism, neuroplasticity, and neuronal activity. Dysregulated or excessive cytokine production can disrupt neuronal metabolic processes and contribute to brain dysfunction. Among the proposed mechanisms underlying the development and progression of affective disorders (ADs), the cytokine hypothesis emphasizes the role...
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