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Article

The murine platelet and plasma factor V pools are biosynthetically distinct and sufficient for minimal hemostasis.

Blood - 15 Oct 2003

Sun Hongmin, Yang Tony L, Yang Angela, Wang Xixi, Ginsburg David

Abstract excerpt

Coagulation factor V (FV) is a central regulator of the coagulation cascade. Circulating FV is found in plasma and within platelet alpha granules. The specific functions of these distinct FV pools are uncertain. We now report the generation of transgenic mice with FV gene expression restricted to either the liver or megakaryocyte/platelet lineage using bacterial artificial chromosome (BAC) constructs. Six of 6...

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Identifiers

PMID: 12855561
DOI: 10.1182/blood-2003-04-1225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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