Article
Extrahepatic sources of factor VIII potentially contribute to the coagulation cascade correcting the bleeding phenotype of mice with hemophilia A.
Haematologica - 1 Jul 2015
Zanolini Diego, Merlin Simone, Feola Maria, Ranaldo Gabriella, Amoruso Angela, Gaidano Gianluca, Zaffaroni Mauro, Ferrero Alessandro, Brunelleschi Sandra, Valente Guido, Gupta Sanjeev, Prat Maria, Follenzi Antonia
Abstract excerpt
A large fraction of factor VIII in blood originates from liver sinusoidal endothelial cells although extrahepatic sources also contribute to plasma factor VIII levels. Identification of cell-types other than endothelial cells with the capacity to synthesize and release factor VIII will be helpful for therapeutic approaches in hemophilia A. Recent cell therapy and bone marrow transplantation studies indicated that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.