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Article

A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII.

Blood - 12 Jun 2014

Fahs Scot A, Hille Matthew T, Shi Qizhen, Weiler Hartmut, Montgomery Robert R

Abstract excerpt

The cellular source of coagulation factor VIII (FVIII) remains controversial. Like many coagulation proteins, FVIII is produced in the liver, and FVIII synthesis has long been associated with hepatocytes. But extrahepatic synthesis also occurs, and mounting evidence suggests that hepatocytes are not responsible for FVIII production. To determine the tissue that synthesizes FVIII, we developed a Cre/lox-dependent...

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Identifiers

PMID: 24705491
DOI: 10.1182/blood-2014-02-555151
PMCID: PMC4055921

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