Article
Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review.
Current drug targets - 1 Jan 2016
Xie Yuanchao, Ogah Comfort Alicha, Jiang Xiangrui, Li Jianfeng, Shen Jingshan
Abstract excerpt
Nowadays, a large number of people in the world are suffering from chronic Hepatitis C. HCV NS5B polymerase conserved across the identified 7 HCV genotypes is considered to be the most promising target in combating HCV. During the past decade, significant progress has been made in the discovery of novel nucleoside HCV NS5B polymerase inhibitors. A potent anti-HCV drug, sofosbuvir with high cure rates has been...
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