Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatitis C therapy with HCV NS5B polymerase inhibitors.

Expert opinion on pharmacotherapy - 1 Jun 2013

Soriano Vincent, Vispo Eugenia, de Mendoza Carmen, Labarga Pablo, Fernandez-Montero Jose Vicente, Poveda Eva, Treviño Ana, Barreiro Pablo

Abstract excerpt

INTRODUCTION: Several HCV polymerase inhibitors are in advanced stages of clinical development. They are nucleos(t)ide and non-nucleoside analogs. Nucleos(t)ides inhibit viral replication acting as chain terminators whereas non-nucleosides block allosterically the HCV polymerase. Sofosbuvir is an uridine analog and currently the most promising HCV polymerase inhibitor, being active across all HCV genotypes. It...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Design
Share to Enzyme Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis C, Chronic

Share to Nucleosides

Share to Nucleotides

Share to RNA-Dependent RNA Polymerase

Share to Viral Nonstructural Proteins

Share to Virus Replication

Source

Identifiers

PMID: 23621117
DOI: 10.1517/14656566.2013.795543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepatitis C therapy with HCV NS5B polymerase inhibitors.PMID 23621117Read ↗

Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review.Semantic proximity Read ↗

Sofosbuvir, a nucleotide polymerase inhibitor, for the treatment of chronic hepatitis C virus infectionSemantic proximity Read ↗

Antiviral therapy with nucleotide polymerase inhibitors for chronic hepatitis C.Semantic proximity Read ↗

Bemnifosbuvir (BEM, AT-527), a novel nucleotide analogue inhibitor of the hepatitis C virus NS5B polymerase.Semantic proximity Read ↗

Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C.Semantic proximity Read ↗

Investigational nucleoside and nucleotide polymerase inhibitors and their use in treating hepatitis C virusSemantic proximity Read ↗

Direct-acting antiviral agents for hepatitis C: structural and mechanistic insights.Semantic proximity Read ↗

Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5BSemantic proximity Read ↗

What is the role of sofosbuvir in treating hepatitis C infection?Semantic proximity Read ↗

Review article: the efficacy and safety of sofosbuvir, a novel, oral nucleotide NS5B polymerase inhibitor, in the treatment of chronic hepatitis C virus infection.Semantic proximity Read ↗

Dual sofosbuvir and ribavirin therapy for chronic hepatitis C infection.Semantic proximity Read ↗

Emerging therapies for hepatitis C virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.