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Nucleotide Prodrugs for HCV Therapy

23 Aug 2011

Abstract excerpt

HCV infection is a significant worldwide health problem and is a major cause of hepatocellular carcinoma. The current standard of care, interferon and ribavirin, is only effective against a proportion of the patient population infected with HCV. To address the shortcomings of existing therapy, the development of direct acting antiviral agents is under investigation. The HCV RNA dependent RNA polymerase is an...

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PMID: 21860070
DOI: 10.3851/imp1797

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