Article
Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A.
Journal of medicinal chemistry - 13 Mar 2014
DeGoey David A, Randolph John T, Liu Dachun, Pratt John, Hutchins Charles, Donner Pamela, Krueger A Chris, Matulenko Mark, Patel Sachin, Motter Christopher E, Nelson Lissa, Keddy Ryan, Tufano Michael, Caspi Daniel D, Krishnan Preethi, Mistry Neeta, Koev Gennadiy, Reisch Thomas J, Mondal Rubina, Pilot-Matias Tami, Gao Yi, Beno David W A, Maring Clarence J, Molla Akhter, Dumas Emily, Campbell Andrew, Williams Laura, Collins Christine, Wagner Rolf, Kati Warren M
Abstract excerpt
We describe here N-phenylpyrrolidine-based inhibitors of HCV NS5A with excellent potency, metabolic stability, and pharmacokinetics. Compounds with 2S,5S stereochemistry at the pyrrolidine ring provided improved genotype 1 (GT1) potency compared to the 2R,5R analogues. Furthermore, the attachment of substituents at the 4-position of the central N-phenyl group resulted in compounds with improved potency....
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