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Article

Phosphorothioate di- and trinucleotides as a novel class of anti-hepatitis B virus agents.

Antimicrobial agents and chemotherapy - 1 Jun 2004

Iyer Radhakrishnan P, Jin Yi, Roland Arlene, Morrey John D, Mounir Samir, Korba Brent

Abstract excerpt

Several nucleoside analogs are under clinical development for use against hepatitis B virus (HBV). Lamivudine (3TC), a nucleoside analog, and adefovir dipivoxil (ADV), an acyclonucleotide analog, are clinically approved. However, long-term treatment can induce viral resistance, and following the cessation of therapy, viral rebound is frequently observed. There continues to be a need for new antiviral agents with...

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Identifiers

PMID: 15155222
DOI: 10.1128/AAC.48.6.2199-2205.2004
PMCID: PMC415564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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